Author(s):
Zeinab Moosavi, Payman Hashemi, Ali Mohammadzadeh
Email(s):
a.mohammadzadeh2023@yahoo.com
DOI:
10.52711/2231-5691.2024.00035
Address:
Zeinab Moosavi1, Payman Hashemi2, Ali Mohammadzadeh2*
1Lorestan University of Medical Science, Khoramabad, Iran.
2Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, Iran.
3Department of Chemistry, Faculty of Science, Arak Branch, Islamic Azad University, Arak, Iran.
*Corresponding Author
Published In:
Volume - 14,
Issue - 3,
Year - 2024
ABSTRACT:
In this study Fe3O4/SiO2/Agarose/Fe3+ magnetic nanoparticle was synthesized based on a simple co-precipitation technique and applied for the drug delivery approach. The modified magnetic nanoparticles were characterized with some techniques such as Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), scanning electron microscopy (SEM) and energy dispersive x-ray spectroscopy (EDX). The magnetic nanoparticles size was less than 17nm and applied as carrier for metformin. In the achieved optimum conditions at pH = 9, time = 5 min, temperature = 20?C and 5ml adsorbent, a high loading capacity of (41.4mg g-1) was obtained for a 1000mg L-1 solution of metformin. The short adsorption time indicates the rapid uptake of the drug onto the nanoparticle carrier. Up to 52% of the drug was loaded on the carrier under the optimal conditions. The method has relative standard deviation (RSD) less than 11.8% (n=10). The proposed method has been successfully applied as a carrier of Metformin.
Cite this article:
Zeinab Moosavi, Payman Hashemi, Ali Mohammadzadeh. Synthesis and Fabrication of Fe3O4/SiO2/Agarose/Fe3+ Magnetic Nanoparticle and its Application in Drug Delivery: Metformin Approach. Asian Journal of Pharmaceutical Research. 2024; 14(3):221-6. doi: 10.52711/2231-5691.2024.00035
Cite(Electronic):
Zeinab Moosavi, Payman Hashemi, Ali Mohammadzadeh. Synthesis and Fabrication of Fe3O4/SiO2/Agarose/Fe3+ Magnetic Nanoparticle and its Application in Drug Delivery: Metformin Approach. Asian Journal of Pharmaceutical Research. 2024; 14(3):221-6. doi: 10.52711/2231-5691.2024.00035 Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2024-14-3-4
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