Author(s): Himanshu Solanki, Harsh Desai, Sumit Singh, Jai Naik

Email(s): drhimanshusolanki7ssrcp@gmail.com

DOI: 10.52711/2231-5691.2024.00001   

Address: Himanshu Solanki*, Harsh Desai, Sumit Singh, Jai Naik
SSR College of Pharmacy, Sayli Road, Silvassa, UT of DNHDD, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2024


ABSTRACT:
The objective of this research is to develop a single unit capsule containing dual release gastro- retentive floating tablet of cinnarizine using polymers such as HPMC as a matrix forming agent, Ethyl cellulose as release retarding agent and Sodium bicarbonate as gas generating agent. Dual release consists of immediate release dose (IR) (loading dose) 25mg of cinnarizine in powder form and 50mg of sustain release tablet (maintenance dose) that will give drug release up to 12hr. The only target was to increase the gastric residence time by using floating approach, thus leading to increase in bioavailability. The direct compression method was used to create the initial batches of the medication, polymers, gas producing agent, and diluent. 32 factorial design was used to optimize the ingredient level. The optimized batches then were characterized for various parameters such as weight variation, thickness, hardness, Floating lag time, swelling study, FTIR etc. It was found that IR (loading dose) while SR of cinnarizine exhibited more than 80% drug release till 12hr. FTIR studies reveled that the drug was compatible with all other excipients. Through optimization, it was concluded that the amount of polymer and gas generating agent directly affect floating lag time and % drug release. SR tablet of cinnarizine of batch F5 showed drug release more than 99% in 12 hr. Thus, the tablet was then packed in capsule and stored at proper conditions.


Cite this article:
Himanshu Solanki, Harsh Desai, Sumit Singh, Jai Naik. Development of Sustained Release Oral Floating Tablet Formulation of Cinnarizine using 32 factorial design. Asian Journal of Pharmaceutical Research. 2024; 14(1):1-9. doi: 10.52711/2231-5691.2024.00001

Cite(Electronic):
Himanshu Solanki, Harsh Desai, Sumit Singh, Jai Naik. Development of Sustained Release Oral Floating Tablet Formulation of Cinnarizine using 32 factorial design. Asian Journal of Pharmaceutical Research. 2024; 14(1):1-9. doi: 10.52711/2231-5691.2024.00001   Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2024-14-1-1


REFERENCES:
1.    Jassal M. Nautiyal U. Kundlas J. Singh D. A review: Gastroretentive drug delivery system (grdds). Indian Journal of Pharmaceutical and Biological Research. 2015; 3(1): 82-92. https://doi.org/10.30750/ijpbr.3.1.13
2.    Vishwakarma SK. Mishra JN. Vishwakarma DK. A review on grdds recent advances in drug delivery systems and its application. World Journal of Pharmaceutical Research. 2021; 10(11): 1159-1175. 10.20959/wjpr202111-21554
3.    Tripathi J. Tapa P. Maharjan R. Jeong SH. Current State and Future Perspectives on Gastroretentive Drug Delivery Systems. Pharmaceutics. 2019; 11(4): 193-215. https://doi.org/10.3390/pharmaceutics11040193
4.    Zanke AA. Gangurde HH. Ghonge AB. Chavan PS. Recent Advance in Gastroretantive Drug Delivery System (GRDDS). Asian Journal of Pharmaceutical Research. 2022; 12(2): 143-149. DOI: 10.52711/2231-5691.2022.00022
5.    Preethi G. Ramesh K. Vijaykumar G. Formulation and evaluation of cinnarazine non effervescent floating tablets. EPRA International Journal of Research and Development. 2020; 5(9): 183-187. https://doi.org/10.36713/epra2016
6.    Streubel A. Sieomann J. Bodmeier R. Gastroretentive drug delivery systems. Expert Opinion on Drug Delivery. 2006; 3(2): 217-233. 10.1517/17425247.3.2.217
7.    Parikh DC. Amin AF. In vitro and in vivo techniques to assess the performance of gastro-retentive drug delivery systems: a review. Expert Opinion on Drug Delivery. 2008; 5(9): 951-965. 10.1517/17425240802318976
8.    Lin HL. Chen LC. Cheng WT. Cheng WJ. Ho HO. Sheu MT. Preparation and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) for Enhanced Oral Bioavailability of Nilotinib. Pharmaceutics. 2020; 12(2): 137-152. doi:10.3390/pharmaceutics12020137
9.    Emanuel M.B. Will WA. Cinnarizine in the treatment of peripheral vascular disease: mechanisms related to its clinical action. Proceedings of the Royal Society of Medicine. 1977; 70(8): 7-12. https://journals.sagepub.com/doi/pdf/10.1177/00359157770700S802
10.    Rouge N. Buri P. Doelker E. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. International Journal of Pharmaceutics. 1996; 136(1-2): 117-139. https://www.sciencedirect.com/science/article/pii/0378517396852008
11.    Raghuvanshi S. Pathak K. Recent Advances in Delivery Systems and Therapeutics of Cinnarizine: A Poorly Water-Soluble Drug with Absorption Window in Stomach. Journal of Drug Delivery. 2014: 1-14. http://dx.doi.org/10.1155/2014/479246
12.    Kirtane MV. Prashant AB. Santani NR. Cinnarizine: A Contemporary Review. Indian Journal of Otolaryngology and Head and Neck Surgery. 2017; 71: 1060-1068. DOI 10.1007/s12070-017-1120-7
13.    Ammar HO. Ghorab M. Kamel R. Salama AH. Design and optimization of gastro-retentive micro balloons for enhanced bioavailability of cinnarizine. Drug Delivery and Translation Research. 2016; 6: 210-224. DOI 10.1007/s13346-016-0280-4
14.    Gu CH. Rao D. Gandhi RB. Hilden J. Raghavan K. Using a Novel Multicompartment Dissolution System to Predict the Effect of Gastric pH on the Oral Absorption of Weak Bases with Poor Intrinsic Solubility. Journal of Pharmaceutical Science. 2005; 94(1): 199-208. https://doi.org/10.1002/jps.20242
15.    Bergström CAS. Fagerberg J. Tsinman O. Tsinman K. Avdeef A. Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids. Molecular Pharmaceutics. 2010; 5: 1801. DOI: 10.1021/mp100049m
16.    Indian Pharmacopoeia 2018 VOL-1. The Indian pharmacopoeia commission Ghaziabad. Government of India, Ministry of Health and Family Welfare.
17.    Kalyankar TM. Wadher SJ. Kulkarni PD. Panchakshari PP. Simultaneous Estimation and Development of UV Spectroscopic Method for Determination of Cinnarizine and Domperidone in Bulk and Pharmaceutical Formulation. International Journal of PharmTech Research. 2014; 6(1): 323-329
18.    Rao NG. Kulkarni U. Patil BS. Design and development of fast dissolving Cinnarizine tablets by sublimation technique. Research Journal of Pharmacy and Technology. 2011; 4(4): 585-588.
19.    Nagasree K. Prashanthi U. Ramya SS, Preparation and Evaluation of Viloxazine Hydrochloride Bilayer Matrix Tablets. Asian Journal of Research in Chemistry. 2023; 16(1): 91-96
20.    Chinta R. Rohini P. Formulation development of Empagliflozin and Metformin hydrochloride extended-release Tablets. Optimization of Formulation using statistical experimental design. Research Journal of Pharmacy and Technology. 2021; 14(3): 1201-1208.
21.    Kavugoli N. Narayanaswamy VB.  Formulation and evaluation of controlled release matrix tablets of labetalol HCl. Asian Journal of Pharmaceutical Research. 2016; 6(2): 107-120
22.    Nishanth I. Elango K. Deattu N. Stephen P. Formulation Development and Evaluation of Bilayer Tablets of Telmisartan for Immediate Release and Metformin Hydrochloride for Sustained Release. Research Journal of Pharmaceutical Dosage forms and Technology. 2013; 5(3): 139-144
23.    Shyamaladevi D. Kumar SS. Formulation and evaluation of bilayer tablets of Montelukast sodium immediate release and Doxofylline sustained release. Research Journal of Pharmacy and Technology. 2013; 6(12): 1370-1374
24.    Shanmugam S. Sandhiya KM. Ayyappan T. Sundarammoorthy K. Vetrichelvan T. Design and In Vitro Studies of Ambroxol Hydrochloride Sustained Release Matrix Tablets. Research Journal of Pharmaceutical Dosage Forms and Technology. 2011; 3(2): 47-51  
25.    Hajare AA. Patil VA. Hajare AA, Patil VA. Formulation and characterization of metformin hydrochloride floating tablets. Asian Journal of Pharmaceutical Research. 2012; 2(3): 111-117
26.    Patil P. Rao BS. Kulkarni SV. Surpur C. Ammanage A. Formulation and in vitro evaluation of floating matrix tablets of ofloxacin. Asian Journal of Research in Pharmaceutical Science. 2011; 1(1): 17-22
27.    Bharadwaj P. Singh R. Swarup A. Development and characterization of newer floating film bearing 5-fluorouracil as a model drug. Journal of Drug Delivery Science and Technology. 2014; 24(5): 486-490. https://doi.org/10.1016/S1773-2247(14)50092-5
28.    Mushtaque M. Muhammad IN. Hassan SM. Ali A. Masood R. Development and pharmaceutical evaluation of oral fast dissolving thin film of escitalopram: A patient friendly dosage form. 2020; 33(1): 183-189. doi.org/10.36721/PJPS.2020.33.1.REG.183-189.1




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