Author(s): Dasari Nirmala, Swapna Nandhini, M. Sudhakar

Email(s): dasarinirmala1980@gmail.com

DOI: 10.5958/2231-5691.2016.00012.5   

Address: Dasari Nirmala, Swapna Nandhini, M. Sudhakar
Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally and Secunderabad -500100 Affiliated to Osmania University
*Corresponding Author

Published In:   Volume - 6,      Issue - 2,     Year - 2016


ABSTRACT:
Present research was aimed with the objective of formulation of Zolpidem fast dissolving oral films, for rapid dissolution of drug and absorption, which may produce the rapid on set off action. The fast dissolving oral films were prepared by solvent casting method using various polymers like HPMC E5, HPMC E15, HPMC K15, microcrystalline cellulose and poly vinyl alcohol. Glycerol used as plasticizer. Prepared films were evaluated for various physicochemical parameters like film thickness, tensile strength, folding endurance, content uniformity, estimation of moisture content, disintegration studies and dissolution studies. As polymer concentration increases thickness increases. Thickness directly proportion to tensile strength so as thickness increases tensile strength also increases. Folding endurance increases as polymer concentration increases. The moisture uptake studies revealed that, the film take up very little moisture (1-2%) in high humid environment, hence this may favors the stability as well as compatability. In vitro drug release studies reveals that among all formulations F7 formulation highest amount of drug release compared to other formulations, hence F7 formulation was taken as optimized formulation for further studies. Short term stability studies were conducted for optimized formulation up to 3 months at 40±2c 75% R.H. after stability studies films were transparent all physical parameters were favorable and drug release was satisfactory.


Cite this article:
Dasari Nirmala, Swapna Nandhini, M. Sudhakar. Design and evaluation of fast dissolving oral films of Zolpidem by solvent casting method. Asian J. Pharm. Res. 2016; 6(2): 67-71. doi: 10.5958/2231-5691.2016.00012.5

Cite(Electronic):
Dasari Nirmala, Swapna Nandhini, M. Sudhakar. Design and evaluation of fast dissolving oral films of Zolpidem by solvent casting method. Asian J. Pharm. Res. 2016; 6(2): 67-71. doi: 10.5958/2231-5691.2016.00012.5   Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2016-6-2-2


Recomonded Articles:

Author(s): Ravi Kumar, Komal

DOI: 10.5958/2231-5691.2021.00003.4         Access: Open Access Read More

Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00016.9         Access: Open Access Read More

Author(s): Rutuja R. Shah, Rohan R. Vakhariya

DOI: 10.5958/2231-5691.2020.00003.9         Access: Open Access Read More

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00024.7         Access: Open Access Read More

Author(s): Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Pankaj Sadashiv Gajare, Sapna Kashyap

DOI: 10.5958/2231-5691.2016.00028.9         Access: Open Access Read More

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00028.4         Access: Open Access Read More

Author(s): Snehal B. Kulkarni, M. M. Bari,S. D. Barhate, Ashutosh Tripath

DOI: 10.5958/2231-5691.2019.00003.0         Access: Open Access Read More

Author(s): Dasari Nirmala, Swapna Nandhini, M. Sudhakar

DOI: 10.5958/2231-5691.2016.00012.5         Access: Open Access Read More

Author(s): Niyaz Kavugoli, Ravikumar, Narayanaswamy VB

DOI: 10.5958/2231-5691.2016.00018.6         Access: Open Access Read More

Author(s): Mukul Ahmed, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque

DOI: 10.5958/2231-5691.2016.00020.4         Access: Open Access Read More

Author(s): K. Vijaya Sri, R. Harish Kumar Reddy , R. Mahesh

DOI:         Access: Open Access Read More

Author(s): P. K. Wagh, S. P. Ahirrao, S. J. Kshirsagar

DOI: 10.5958/2231-5691.2019.00013.3         Access: Open Access Read More

Author(s): Injamamul Haque, Ravikumar, Narayanaswamy VB, Mohibul Hoque

DOI: 10.5958/2231-5691.2016.00023.X         Access: Open Access Read More

Author(s): Girish Pai K., Vamshi Krishna T., Lalit Kumar, M. Sreenivasa Reddy, G. Shreenidhi, A. Praneeth Reddy

DOI:         Access: Open Access Read More

Author(s): Prakash Goudanavar, Doddayya Hiremath, Spandana D. , S. R. Reddy

DOI:         Access: Open Access Read More

Author(s): Batra Neha, Jain Honey, Bairwa Ranjan, Bachwani Mukesh

DOI:         Access: Open Access Read More

Author(s): Sugiyartono, Tutiek Purwanti, Isnaeni, Dhenok Reso Fenda Asega

DOI:         Access: Open Access Read More

Author(s): Mamatha Kola, Subharna Mallik, Pranusha Palle, Pallavi Kamarapu

DOI:         Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5691 


Recent Articles




Tags