Author(s): K. Vijaya Sri, S. Sravani, M. Shiva Kumar

Email(s): vijayasree_2002@yahoo.co.in

DOI: 10.5958/2231-5691.2015.00015.5   

Address: K. Vijaya Sri*, S. Sravani, M. Shiva Kumar
Department of Pharmaceutical Analysis, Malla Reddy College of Pharmacy, Secunderbad Telangana
*Corresponding Author

Published In:   Volume - 5,      Issue - 2,     Year - 2015


ABSTRACT:
The UV-spectroscopic method were developed and validated for the estimation of Lurasidone HCl as per ICH guidelines. A simple, fast, accurate and precise UV-spectroscopy method was developed by using methanol: water (70:30v/v) and acetonitrile: water (50:50v/v) was used as the solvent in both methods. The ?max of Lurasidone was found to be 230 nm and it was proved linear in the concentration range of 2.5–15 µg/ml with a correlation coefficient value of 0.999 for both the methods. The accuracy studies of UV-spectroscopy method was performed at three different levels, i.e., 50%, 100%, and 150% and recovery was found to be in the range of 99.2 to 102.4% respectively. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.61-0.69 for both UV Method. The % RSD is <2% which indicates the accuracy and precision of the method.


Cite this article:
K. Vijaya Sri, S. Sravani, M. Shiva Kumar. Development and Validation of UV Spectrophotometric Method for Estimation of Lurasidone in Bulk and Pharmaceutical Formulations. Asian J. Pharm. Res. 5(2): April-June 2015; Page 102-107. doi: 10.5958/2231-5691.2015.00015.5

Cite(Electronic):
K. Vijaya Sri, S. Sravani, M. Shiva Kumar. Development and Validation of UV Spectrophotometric Method for Estimation of Lurasidone in Bulk and Pharmaceutical Formulations. Asian J. Pharm. Res. 5(2): April-June 2015; Page 102-107. doi: 10.5958/2231-5691.2015.00015.5   Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2015-5-2-6


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DOI: 10.5958/2231–5691 


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