Author(s):
Madhuri Deshmukh, Prajakta Zirmire, Pavan Ingole, Tejaswini Deshmukh, Vikram Deshmukh, Arpana Patil
Email(s):
madhurideshmukh9@yahoo.com
DOI:
10.52711/2231-5691.2025.00043 
Address:
Madhuri Deshmukh1, Prajakta Zirmire2, Pavan Ingole3, Tejaswini Deshmukh4, Vikram Deshmukh5, Arpana Patil6
1,2,3,6Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk.), Pune - 411048, Maharashtra, India.
4SVPM’S College of Pharmacy, Malegaon (Bk), Baramati - 413115, Maharashtra, India.
5College of Pharmacy and Research center Phaltan, Satara - 415012, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 3,
Year - 2025
ABSTRACT:
Salbutamol sulphate, a short-acting, selective ß1-adrenergic receptor agonist used in the treatment of asthma (BCS Class III), is metabolized by oxidative deamination and excreted in the urine, resulting in a bioavailability of approximately 50%. To improve its bioavailability and physical stability, Salbutamol sulphate nanostructured lipid carriers (NLCs) were developed. These NLCs were prepared using the melt emulsification ultrasonication technique with Glyceryl monostearate and Capmul PG-8-70 NF. The analysis of the NLCs was conducted using FT-IR, XRD, PDI, zeta potential, and DSC parameters. In this study, the prepared NLCs were further developed into an in-situ gel. This Salbutamol sulphate-loaded NLC-based in-situ gel shows promise as a suitable nasal delivery system for the treatment of asthma. The optimized formulation exhibited a particle size of 85.6nm, a polydispersity index of 0.270, and a zeta potential of -19.41mV. The entrapment efficiency varied from 72.5% to 82.5%, accompanied by a drug loading of 1.81%. TEM images confirmed that the particles were spherical in shape. The in-vitro diffusion study and ex-vivo permeation study of the optimized nasal gel showed superior results compared to the marketed formulation. The results indicate the safety of Salbutamol sulphate NLC in situ nasal gel and its potential to enhance medication bioavailability
Cite this article:
Madhuri Deshmukh, Prajakta Zirmire, Pavan Ingole, Tejaswini Deshmukh, Vikram Deshmukh, Arpana Patil. Preparation and Evaluation of Salbutamol Sulphate Loaded Nano Structured Lipid Carriers. Asian Journal of Pharmaceutical Research. 2025; 15(3):269-3. doi: 10.52711/2231-5691.2025.00043
Cite(Electronic):
Madhuri Deshmukh, Prajakta Zirmire, Pavan Ingole, Tejaswini Deshmukh, Vikram Deshmukh, Arpana Patil. Preparation and Evaluation of Salbutamol Sulphate Loaded Nano Structured Lipid Carriers. Asian Journal of Pharmaceutical Research. 2025; 15(3):269-3. doi: 10.52711/2231-5691.2025.00043 Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2025-15-3-7
REFERENCES:
1. Alhalaweh A, Sokolowski A, Rodríguez-Hornedo N, Velaga SP. Solubility behavior and solution chemistry of indomethacin cocrystals in organic solvents. Crystal Growth and Design. 2011; 11(9): 3923-3929.
2. Chandana KV, Gupta NV, Kanna S. Nanostructured lipid carriers: The frontiers in drug delivery. Asian J Pharm Clin Res. 2019; 12(7): 8-12.
3. Gater A, Nelsen L, Fleming S, Lundy JJ, Bonner N, Hall R, et al. Assessing asthma symptoms in adolescents and adults: qualitative research supporting development of the asthma daily symptom diary. Value in Health. 2016; 19(4): 440-450.
4. Deshmukh MT, Mohite SK. Formulation and characterization of olanzepine loaded mucoadhesive microspheres. Asian J Pharm Clin Res. 2017; 10(4): 249-255.
5. Kausalya S. Optimization of Ibuprofen Loaded Nanostructured Lipid Carrier (NLC) Using Response Surface Methodology (RSM): Preparation and Invitro Evaluation: CL Baid Metha College of Pharmacy, Chennai. 2019.
6. Deshmukh V, Pawar A, Deshmukh T, Deshmukh M, Katedeshmukh R, Patil R. Preparation and evaluation of slow-release carbamazepine alginate-talc beads. Current Pharma Research. 2011;1(3): 271-279.
7. Fernandes A , Pydi C , Verma R , Jose J , Kumar L. Design, preparation and in- vitro characterizations of fluconazole loaded nanostructured lipid carriers. Braz. J. Pharm. Sci. 2020; 56(e18069): 1-14.
8. Patel D, Dasgupta S, Dey S, Roja Ramani Y, Ray S, Mazumder B. Nanostructured lipid carriers (NLC)-based gel for the topical delivery of aceclofenac: preparation, characterization, and in vivo evaluation. Scientia Pharmaceutica. 2012; 80(3): 749-764.
9. Senthil P, Arivuchelvan A, Jagadeeswaran A, Subramanian N, Senthil C, Mekala P. Formulation, optimization and evaluation of enrofloxacin solid lipid nanoparticles for sustained oral delivery. Asian J Pharm Clin Res. 2015; 8: 231-6.
10. Patil-Gadhe A, Pokharkar V. Montelukast-loaded nanostructured lipid carriers: part I oral bioavailability improvement. European Journal of Pharmaceutics and Biopharmaceutics. 2014; 88(1): 160-168.
11. Payghan SA. Preparation and characterization of molecular complexes of fenofibrate cocrystal. Asian Journal of Pharmaceutics (AJP). 2017;11(04).
12. Singh H, Gupta RD, Gautam G. Formulation development, characterization, and in vitro-in vivo study of antihyperlipidemic drug rosuvastatin calcium-solid lipid nano particles. Asian J Pharm Clin Res. 2018; 11: 436-43.
13. Salunke SR, Patil SB. Ion activated in situ gel of gellan gum containing salbutamol sulphate for nasal administration. International Journal of Biological Macromolecules. 2016; 87: 41-47.
14. Singh H, Gupta R, Gautam G. Formulation development, characterization, and in vitro-in vivo study of antihyperlipidemic drug rosuvastatin calcium—solid lipid nanoparticles. Asian J Pharm Clin Res. 2018; 11(7): 436.
15. Zhang X, Liu J, Qiao H, Liu H, Ni J, Zhang W, et al. Formulation optimization of dihydroartemisinin nanostructured lipid carrier using response surface methodology. Powder Technology. 2010; 197(1-2): 120-128.
16. 16.Fahm U, Ahme O, Badr-Eldin S, Badr-Eldin S, Okbazghi S, Bakhrebah M, Alomary M, Abdulaa W, Medina C. Optimized Nanostructured Lipid Carriers Integrated into In Situ Nasal Gel for Enhancing Brain Delivery of Flibanserin. International Journal of Nanomedicine. 2020: 15; 5253-5264.
17. Jangde RK, Khan T, Bhardwaj H. Development and Characterization of Nanostructured Lipid Carrier for Topical delivery of Naringenin. Res J Pharm Tech. 2023;16(5):2572-2576.
18. Sarma A, Das MK, Chakraborty T, Das S. Nanostructured lipid carriers (NLCs)-based intranasal Drug Delivery System of Tenofovir disoproxil fumerate (TDF) for brain targeting. Res J Pharm Tech. 2020; 13(11): 5411-5424.
19. Bornare AS, Saudagar RB. Nanostructured Lipid Carrier (NLC): A Modern Approach for Transdermal Drug Delivery. Res J Pharm Tech. 2017; 10(8): 2784-2792.
20. Jain AK, Mehta P. Co-administration of Adapalene loaded Nanostructured lipid carriers and Vitamin-E for management of acne. Res J Pharm Tech. 2023; 16(11): 5067-5073.