Author(s):
Anuradha Parixit Prajapati, Hardik Bharatbhai Prjapati, Kantilal Narkhede, Neha Desai, Mansi Barot, Shailesh Luhar, Sachin Narkhede
Email(s):
anupatel03@gmail.com
DOI:
10.52711/2231-5691.2026.00033 
Address:
Anuradha Parixit Prajapati, Hardik Bharatbhai Prjapati, Kantilal Narkhede, Neha Desai, Mansi Barot, Shailesh Luhar, Sachin Narkhede
Department of Pharmaceutics, Smt. BNB Swaminarayan Pharmacy College, Salvav, Vapi, Gujarat, India, 396191.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2026
ABSTRACT:
Objective: This study aimed to develop a press-coated pulsatile tablet of Fimasartan Potassium Trihydrate (FPT) to enhance bioavailability and achieve timed drug release for effective morning hypertension management. Methods: To improve the solubility and permeability of BCS Class IV FPT, an inclusion complex with Hydroxypropyl-ß-Cyclodextrin (HP-ß-CD) in a 1:2 molar ratio was prepared using the kneading method. Characterization using Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) confirmed complex formation. Core tablets, formulated with Croscarmellose sodium as a superdisintegrant, were press-coated with Hydroxypropyl Methylcellulose (HPMC K4M) and Ethyl cellulose. A 3² factorial design was applied to evaluate the impact of HPMC K4M concentration and coating polymer amount on lag time and drug release. Results: Pre- and post-compression studies confirmed satisfactory tablet properties. The optimized formulation exhibited a lag time of 266 minutes and achieved 90% drug release within 302 minutes, ensuring drug availability during the early morning blood pressure surge. Conclusion: The developed press-coated pulsatile tablet successfully provided controlled, time-specific drug release, improving therapeutic effectiveness and patient adherence. This formulation represents a promising chronotherapeutic approach for hypertension and heart failure management.
Cite this article:
Anuradha Parixit Prajapati, Hardik Bharatbhai Prjapati, Kantilal Narkhede, Neha Desai, Mansi Barot, Shailesh Luhar, Sachin Narkhede. Formulation and Evaluation of Press-Coated Pulsatile Tablets of Fimasartan Potassium Trihydrate for Morning Cardiovascular Treatment. Asian Journal of Pharmaceutical Research. 2026; 16(3):221-8. doi: 10.52711/2231-5691.2026.00033
Cite(Electronic):
Anuradha Parixit Prajapati, Hardik Bharatbhai Prjapati, Kantilal Narkhede, Neha Desai, Mansi Barot, Shailesh Luhar, Sachin Narkhede. Formulation and Evaluation of Press-Coated Pulsatile Tablets of Fimasartan Potassium Trihydrate for Morning Cardiovascular Treatment. Asian Journal of Pharmaceutical Research. 2026; 16(3):221-8. doi: 10.52711/2231-5691.2026.00033 Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2026-16-3-1
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