Author(s):
Harshal Patil, Jyotsna Waghmare
Email(s):
harshalvpatil1612@gmail.com , jyotsna.waghmare@gmail.com
DOI:
10.52711/2231-5691.2026.00058 
Address:
Harshal Patil, Jyotsna Waghmare
Department of Oils, Oleochemicals and Surfactant Technology Institute of Chemical Technology (ICT), Nathalal Parikh Marg, Matunga (E), Mumbai - 400019, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2026
ABSTRACT:
This paper describes the design and the overall analysis of a new microemulsion system using Moringa oleifera and Punica granatum seed oils to be used in advanced dermocosmetic product development. Pomegranate seed oil, containing punicalic acid (79.21) was synergistically used with the moringa oil that contained oleic acid (69.34) to produce stable oil-in-water microemulsions. Pseudo-ternary phase diagrams were drawn by use of hydrogenated castor oil ethoxylate 40 moles (HCO-40), grapeseed oil ethoxylate 20 moles (GSO-20) and rapeseed oil ethoxylate 20 moles (RSO-20) as a surfactant at recommended HLB values of 12.1 and 12.7. Optimization of oil blends ratio of 85:15 (Moringa: Pomegranate) gave better physicochemical characteristics with particle size of 87.2-123.7 nm, pHs of 6.90-7.21 and had a great centrifuge stability of up to 30 days. Two dermocosmetic emulsions were formulated and profiled based on physicochemical parameters, sensory qualities, compatibility with the skin, and stability of the two emulsions (a facial serum and hydrating face mist). The facial serum had a viscosity of 120 cps, a pH of 5.6 and a particle size of 104.2 nm whereas the face mist had viscosity of 32 cps, pH 5.4 and particle size of 88.9 nm. Formulations Sensory assessment (n=20) indicated that both formulations had high acceptability scores (4.5-4.9 on a 5-point scale). Skin compatibility tests revealed that the index of irritation was minimal (0.1-0.2) and no allergic response was reported. One month of accelerated stability at 250C, 400C, and 4 0C ensured an excellent physical and chemical stability with little pH variability (+-0.1 to +-0.3) and no phase separation. The formulated microemulsion systems have a strong potential of being efficient drug delivery system of the synergistic bioactive compounds in natural oil-based cosmetic products.
Cite this article:
Harshal Patil, Jyotsna Waghmare. Formulation and Stability Evaluation of Moringa-Pomegranate Oil-Based Microemulsion System for Dermocosmetic Applications. Asian Journal of Pharmaceutical Research. 2026; 16(4):395-3. doi: 10.52711/2231-5691.2026.00058
Cite(Electronic):
Harshal Patil, Jyotsna Waghmare. Formulation and Stability Evaluation of Moringa-Pomegranate Oil-Based Microemulsion System for Dermocosmetic Applications. Asian Journal of Pharmaceutical Research. 2026; 16(4):395-3. doi: 10.52711/2231-5691.2026.00058 Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2026-16-4-5
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