Author(s): Kamma Keerthi Sai

Email(s): marzinaaj@gmail.com

DOI: 10.52711/2231-5691.2024.00032   

Address: Kamma Keerthi Sai*
Assistant Professor, Department of Pharmaceutics, Aditya College of Pharmacy, Aditya Nagar, ADB Road, Surampalem, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2024


ABSTRACT:
The aim of the present study is Formulation and Evaluation of Phenytoin by making solid dispersion with polyvinyl alcohol and inclusion complexation with HPß Cyclodextrin, ß Cyclodextrin. Solid dispersion of Phenytoin is prepared with Solvent Evaporation method. Phenytoin belongs to BCS class II drug which is characterized by high membrane permeability, slow dissolution rate due to low aqueous solubility. It is an anti-epileptic or anti- convulsant is used to treat wide variety of Seizures. The Phenytoin solid dispersions were prepared by solvent evaporation method at 1:0.25, 1:0.5, 1:0.75, 1:1, 1:1.25, 1:1.5 ratios of Phenytoin to HP ß CD, ß CD and PVA. The prepared dispersions were evaluated by solubility studies, in-vitro dissolution studies, melting point determination, drug content uniformity, entrapment efficiency and FT-IR studies. Finally comparing all the formulations (P:HPß F1-P:HPß F6) (P: ßF1-P ßF6) and (P:PF1-P:PF6) formulation P:PF4 containing Phenytoin: Polyvinyl alcohol (1:1) shows better result at the end of 90 min with drug release 93.99%, hence it was selected as the best formulation. By release kinetic studies of best formulation of Phenytoin with zero order and first order we can say that the best formulation follows first order kinetics studies having r2 value 0.945 where as zero order release kinetics studies having r2 value 0.849. The results indicated as formulated solid dispersion tablets displayed better dissolution profiles as compared to existing commercial tablets.


Cite this article:
Kamma Keerthi Sai. Formulation and Evaluation of Solid Dispersion of Phenytoin by Solvent Evaporation Technique. Asian Journal of Pharmaceutical Research. 2024; 14(3):199-5. doi: 10.52711/2231-5691.2024.00032

Cite(Electronic):
Kamma Keerthi Sai. Formulation and Evaluation of Solid Dispersion of Phenytoin by Solvent Evaporation Technique. Asian Journal of Pharmaceutical Research. 2024; 14(3):199-5. doi: 10.52711/2231-5691.2024.00032   Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2024-14-3-1


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