Synthesis of novel 3-[(dialkyl/aryl amino) methyl]-2-substituted-4(3H)-Quinazolinones and evaluation of their Anti-inflammatory activity

Ganesh Akula; Rangu Nirmala; CH. Shanthipriya; S. Rohini Reddy; A. Jaswanth

doi:10.5958/2231-5691.2017.00010.7

Asian Journal of Pharmaceutical Research

ISSN

2231-5691 (Online)
2231-5683 (Print)

Submit Article

Synthesis of novel 3-[(dialkyl/aryl amino) methyl]-2-substituted-4(3H)-Quinazolinones and evaluation of their Anti-inflammatory activity

Author(s): Ganesh Akula, Rangu Nirmala, CH. Shanthipriya, S. Rohini Reddy, A. Jaswanth

Email(s): akulaganesh@gmail.com

DOI: 10.5958/2231-5691.2017.00010.7

Address: Ganesh Akula1*, Rangu Nirmala2, CH. Shanthipriya2, S. Rohini Reddy2, Dr. A. Jaswanth2
1Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312
2Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312
*Corresponding Author

Published In: Volume - 7, Issue - 2, Year - 2017

View HTML

View PDF

ABSTRACT:
Literature survey reveals that in recent years several Quinazolinone derivatives have been synthesized and reported to possess varied biological and pharmacological properties. They are found to be useful as antibacterial, analgesic, anti-inflammatory, antifungal, anticonvulsant and anticancer agents. A new series of 3-[(di alkyl amino) methyl]-2-substituted-4(3H)-Quinazolinones were synthesized by the reaction of a mixture of 2-substituted-4(3H)-Quinazolinone, formaldehyde and dialkyl or diaryl amine by mannich reaction. The chemical structures of the synthesized compounds were confirmed by IR, mass spectral and C, H, N analysis techniques. The synthesized compounds were screened for anti-inflammatory activity by the carrageenan induced rat hind paw edema method. The synthesized compounds were significantly showed their anti-inflammatory activity that of standard.

Keywords:

Cite this article:
Ganesh Akula, Rangu Nirmala, CH. Shanthipriya, S. Rohini Reddy, A. Jaswanth. Synthesis of novel 3-[(dialkyl/aryl amino) methyl]-2-substituted-4(3H)-Quinazolinones and evaluation of their Anti-inflammatory activity. Asian J. Pharm. Res. 2017; 7(2): 60-62. doi: 10.5958/2231-5691.2017.00010.7

Cite(Electronic):
Ganesh Akula, Rangu Nirmala, CH. Shanthipriya, S. Rohini Reddy, A. Jaswanth. Synthesis of novel 3-[(dialkyl/aryl amino) methyl]-2-substituted-4(3H)-Quinazolinones and evaluation of their Anti-inflammatory activity. Asian J. Pharm. Res. 2017; 7(2): 60-62. doi: 10.5958/2231-5691.2017.00010.7 Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2017-7-2-2

Recomonded Articles:

Pharmacological and Phytochemical Evidences for the Plants of Wedelia Genus– A Review

Author(s): AK Meena, MM Rao, RP Meena, P Panda, Renu

DOI: Access: Open Access Read More

Sublingual Tablets - An Updated Review

Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00016.9 Access: Open Access Read More

Traditional Herbs to treat Acne Vulgaris

Author(s): Sonali Syal, Vinay Pandit, M. S Ashawat

DOI: 10.5958/2231-5691.2020.00034.9 Access: Open Access Read More

The Survey of Knowledge about OTC Drugs among Pharmacy Background and Non-Pharmacy Community

Author(s): Pranit P. Gayakar, Rahul S. Adnaik, Amit D. Jadhav, Shrinivas K. Mohite

DOI: Access: Open Access Read More

Review on Pharmacological Properties of Abutilon indicum.

Author(s): Mohite M S, Shelar P A, Raje V N., Babar S. J., Sapkal R. K.

DOI: Access: Open Access Read More

Eupatorium triplinerve (Vahl): An Ethnobotanical Review

Author(s): Binoy Varghese Cheriyan, Sabartina scarlet, Priyadarshini, Shailesh joshi, Santhseelan, Sheik Mohamed

DOI: 10.5958/2231-5691.2019.00032.7 Access: Open Access Read More

A detailed investigation of phytochemical, biological and commercial utilization of horse tail tree Casuarina equisetifolia

Author(s): Vani Mamillapalli, Latha Sri Kondaveeti, Ratna Harika Chapala, Tejaswi Komal Sai. Sareddu, Santhi Pattipati, Padmalatha Khantamneni

DOI: 10.52711/2231-5691.2022.00014 Access: Open Access Read More

Vitex trifolia -An Important Medicinal Plant: A Review of Its Folklore Medicine and Traditional Uses

Author(s): Goli. Venkateshwarlu, E. Ragyanaik, Kasireddy. Swapna, A. Santhosh, CH. Santhosh

DOI: Access: Open Access Read More

Animal Models for Inflammation: A Review

Author(s): Ghanshyam Dhalendra, Trilochan Satapathy, Amit Roy

DOI: Access: Open Access Read More

Evaluation of Wound Healing Activity of Ethanolic Extract of Curcuma longa Rhizomes in Male Albino Rats

Author(s): S.K. Purohit, R. Solanki, V. Mathur, M. Mathur

DOI: Access: Open Access Read More

Introduction to Pharmacovigilance and Monitoring

Author(s): Manohar D. Kengar, Kiran K. Patole, Akshay K. Ade, Sumesh M. Kumbhar, Chetan D. Patil, Ashutosh R. Ganjave

DOI: 10.5958/2231-5691.2019.00019.4 Access: Open Access Read More

Phytopharmacology of Ficus bengalensis - A Review

Author(s): Prathap Kumar Kothapalli, Jagadeesh. S. Sanganal, N.B. Shridhar

DOI: Access: Open Access Read More

A Review on New Herbal Remedies for treatment of Mouth Ulcer

Author(s): Rina G. Maskare, Ayush P. Agrawal, Mayuri S. Pal, Jidnyasa R. Yerne, Megham Chaudhri, Anup R. Bawankar, Gaytri B. Sonkusre

DOI: 10.52711/2231-5691.2022.00025 Access: Open Access Read More

Emulgel: A Review

Author(s): Sahil Hasan, Saloni Bhandari, Anshu Sharma, Poonam Garg

DOI: 10.52711/2231-5691.2021.00047 Access: Open Access Read More

Ethno Pharmacological Uses of Artocarpus altilis– A Review

Author(s): Vidya Raju*, Jasmine Joy Bell, Merlin. N. J, Shaiju S Dharan

DOI: 10.5958/2231-5691.2017.00037.5 Access: Open Access Read More

Anti-Inflammatory activity of Ethanolic extract of Basella alba in acute and Sub-acute Model

Author(s): Naidu Narapusetty, O. Sivaiah, B. Balanasaraiah, M. Haranadhbabu, B. Prasad, B. Hosanna Crown, Ch. M. M. Prasada Rao

DOI: 10.5958/2231-5691.2017.00015.6 Access: Open Access Read More

Effects of Anti-Inflammatory Activity of Mimosa pudica.

Author(s): Venkateshwarlu Goli, Kanakam Vijay Bhaskar, Sravan Prasad Macharla, Jimmidi.Bhaskar, P. Suvarna Devi, T. Ramchander

DOI: Access: Open Access Read More

Formulation and Evaluation of Herbal Shampoo: Bryophyllum pinnatum

Author(s): Kavya V. Reddy, Ashish V. Yachawad, Krushna K. Zambare, Sopan Landge

DOI: 10.5958/2231-5691.2020.00016.7 Access: Open Access Read More

Murrayanine-Chalcone Transformed into Novel Pyrimidine Compounds Demonstrated promising Anti-Inflammatory Activity

Author(s): Debarshi Kar Mahapatra, Ruchi S. Shivhare, Pranesh Kumar

DOI: 10.5958/2231-5691.2018.00002.3 Access: Open Access Read More

Formulation and Characterization of Metformin Hydrochloride Floating Tablets

Author(s): Ashok A. Hajare, Vrushali A. Patil

DOI: Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available
DOI: 10.5958/2231–5691