Author(s): Chetan Savant, Venkatrao Kulkarni, Prasanna Habbu, Preeti Kulkarni, Muhammed Majeed, Mahadeva Nayak

Email(s): chetan.savant@yahoo.com

DOI: 10.52711/2231-5691.2022.00004   

Address: Chetan Savant1*, Venkatrao Kulkarni1, Prasanna Habbu2, Preeti Kulkarni1, Muhammed Majeed3, Mahadeva Nayak3
1Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka, India.
2Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka, India.
3Sami Labs Limited, R&D Peenya Industrial Area, Bangalore- 560058, Karnataka, India. *Corresponding Author

Published In:   Volume - 12,      Issue - 1,     Year - 2022


ABSTRACT:
Herbal drugs are used widely even when their biologically active compounds are unknown, probably because of their effectiveness, lesser side effects and affordability. In the present study we investigated the potential cardio-protective effect of combination of standardized extracts of Terminalia arjuna and Ocimum sanctum in isoproterenol induced myocardial infarction. Myocardial infarction was induced in rats by subcutaneous injection of Isoproterenol for two consecutive days at an interval of 24h. Rats were pre-treated with test drugs for the period of 21 days and Isoproterenol was administered on 20 and 21st day. At the end of experiment i.e on 22nd day hemodynamic, biochemical and histopathological study of heart tissue were evaluated from control and experimental groups. Isoproterenol treated animals showed significant increase in heart rate and cardiac biomarkers. Whereas, mean arterial blood pressure and antioxidant parameters were significantly decreased. Animals administered with different combinations of standardized extracts of Terminalia arjuna and Ocimum sanctum significantly maintained the levels of cardiac biomarkers, antioxidant parameters, mean arterial pressure and heart rate. Histopathology study showed marked myocardial necrosis in Isoproterenol treated animals and significant cardiac protection of animals treated with extract combinations. Hence, we may conclude that herb-herb combinations were found to be effective in prevention of myocardial injury induced by isoproterenol.


Cite this article:
Chetan Savant, Venkatrao Kulkarni, Prasanna Habbu, Preeti Kulkarni, Muhammed Majeed, Mahadeva Nayak. Pharmacodynamic interaction of Terminalia arjuna (Roxb) with Ocimum sanctum (Linn) in Isoproterenol induced cardiac necrosis. Asian Journal of Pharmaceutical Research. 2022; 12(1):19-3. doi: 10.52711/2231-5691.2022.00004

Cite(Electronic):
Chetan Savant, Venkatrao Kulkarni, Prasanna Habbu, Preeti Kulkarni, Muhammed Majeed, Mahadeva Nayak. Pharmacodynamic interaction of Terminalia arjuna (Roxb) with Ocimum sanctum (Linn) in Isoproterenol induced cardiac necrosis. Asian Journal of Pharmaceutical Research. 2022; 12(1):19-3. doi: 10.52711/2231-5691.2022.00004   Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2022-12-1-4


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DOI: 10.5958/2231–5691 


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