ABSTRACT:
Artemether is a poorly water-soluble antimalarial drug, Its oral bioavailability is limited. The current study's objective was to improve medication release and dissolution by creating and evaluating Artemether immediate-release tablets utilizing the Liquisolid Technique. Direct compression was used to manufacture the tablets, and FTIR and UV spectroscopy were used to characterize them confirms drug integrity and compatibility. The precompression and postcompression properties of eight formulations (TF1–TF8), Drug content, thickness, hardness, friability, weight fluctuation, disintegration time, and in vitro dissolution profile were among the factors that were designed and evaluated. Formulation F8 had the best properties of all, showing better solubility and quick drug availability with a drug content of 99.86±0.02, a disintegration time of 5±0.03 min, and a percentage of drug release of 98.89±0.22 within 25 minutes. The study comes to the conclusion that the liquisolid compact technology is a viable strategy for improving artemether's rate of dissolution and immediate therapeutic impact.
Cite this article:
Rakesh M. Wagh, Rajendra K. Surawase. Formulation and Evaluation of Artemether Tablet by using Liquisolid Technique. Asian Journal of Pharmaceutical Research. 2026; 16(3):229-6. doi: 10.52711/2231-5691.2026.00034
Cite(Electronic):
Rakesh M. Wagh, Rajendra K. Surawase. Formulation and Evaluation of Artemether Tablet by using Liquisolid Technique. Asian Journal of Pharmaceutical Research. 2026; 16(3):229-6. doi: 10.52711/2231-5691.2026.00034 Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2026-16-3-2
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