Author(s):
Avinash A. Gunjal, Ashish V. Kulkarni, Devendra S. Shirode, Prasad K. Bairagi, Vasant Y. Chavan, Niraj S. Vyawahare
Email(s):
avinashgunjal4247@gmail.com
DOI:
10.52711/2231-5691.2026.00035 
Address:
Avinash A. Gunjal*, Ashish V. Kulkarni, Devendra S. Shirode, Prasad K. Bairagi, Vasant Y. Chavan, Niraj S. Vyawahare
Department of Pharmacology, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune - 411044, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2026
ABSTRACT:
L-carnitine-L-tartrate (LCLT) is a supplement form of L-carnitine that is necessary for long-chain fatty acid transport within the mitochondria. This study uses a variety of assays to assess LCLT's in-vitro antioxidant and anti-inflammatory properties. Proteinase inhibitory activity and the albumin denaturation method were used to evaluate the anti-inflammatory potential, while DPPH and H2O2 scavenging assays were used to determine the antioxidant activity. With IC50 values of 282.03 and 270.51µg/mL, respectively, LCLT markedly reduced albumin denaturation and proteinase activity at the same concentrations of 100–500µg/mL. The IC50 values for diclofenac sodium, a common anti-inflammatory drug, were 194.44 and 179.25µg/mL at the same concentrations. With IC50 values of 61.11 and 32.83µg/mL, respectively, LCLT also showed efficient DPPH and H2O2 scavenging activities at doses of 20–100µg/mL and 15–30µg/mL. The IC50 values of ascorbic acid, a common antioxidant, were 45.29µg/mL and 24.24µg/mL. According to these results, LCLT exhibits strong dose-dependent antioxidant and anti-inflammatory properties, indicating that it may be a promising lead molecule for the treatment of oxidative stress and inflammation-related illnesses.
Cite this article:
Avinash A. Gunjal, Ashish V. Kulkarni, Devendra S. Shirode, Prasad K. Bairagi, Vasant Y. Chavan, Niraj S. Vyawahare. In-vitro Anti-inflammatory and Antioxidant Activity of L-carnitine-L-tartrate (LCLT). Asian Journal of Pharmaceutical Research. 2026; 16(3):237-1. doi: 10.52711/2231-5691.2026.00035
Cite(Electronic):
Avinash A. Gunjal, Ashish V. Kulkarni, Devendra S. Shirode, Prasad K. Bairagi, Vasant Y. Chavan, Niraj S. Vyawahare. In-vitro Anti-inflammatory and Antioxidant Activity of L-carnitine-L-tartrate (LCLT). Asian Journal of Pharmaceutical Research. 2026; 16(3):237-1. doi: 10.52711/2231-5691.2026.00035 Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2026-16-3-3
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