Thiocolchicoside and Famotidine are both have known to be used in joint pain or in the treatment of rheumatoid arthritis, etc. But the problem arises in the bioavailability and absorption of these drugs in the body. The current study deals with the design and evaluation of crystal co-agglomerates prepared with the use of various concentration of polymers like HPMC K15M and PVA. The aim of the study was to improvise the flow property, wettability, and dissolution property of the drug and to enhance its absorption in the body which will give better therapeutic response. The prepared co-agglomerates were evaluated for the parameters and it was found that the F4 bath was optimum because better flow ability, maximum drug content and increased dissolution property. SEM study shows the clear cylindrical crystals formed and the stability study shows that the prepared co-agglomerates were stable for the period of time without any significant change in the preparation. It was concluded that the preparation of crystal co-agglomerates was a successful approach in improving the various properties which can reduce the chances of metabolism of drug and will give better therapeutic response and stability of the drug.
Cite this article:
Sushant Bhamburkar, Swanand Patharkar. Design, Development and Evaluation of Thiocolchicoside and Famotidine Agglomerates by Crystallo Co-Agglomeration Technique. Asian Journal of Pharmaceutical Research. 2022; 12(2):125-1. doi: 10.52711/2231-5691.2022.00019
Sushant Bhamburkar, Swanand Patharkar. Design, Development and Evaluation of Thiocolchicoside and Famotidine Agglomerates by Crystallo Co-Agglomeration Technique. Asian Journal of Pharmaceutical Research. 2022; 12(2):125-1. doi: 10.52711/2231-5691.2022.00019 Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2022-12-2-2
1. Gohel, M.C., Parikh, R.K., Shah, H. and Dubey, R.R.,. Improvement in flowability and compressibility of ampicillin trihydrate by spherical crystallization. Indian journal of pharmaceutical sciences, 2003, 65(6), 634.
2. Puechagut, H.G., Bianchotti, J. and Chiale, C.A. Preparation of norfloxacin spherical agglomerates using the ammonia diffusion system. Journal of pharmaceutical sciences, 1998, 87(4), 519-523.
3. Ghosh, B., Patel, J., Bose, P. and Roy, D., Crystallo CO-Agglomeration-A Review., International Journal of Recent Scientific Research. 2018, 9(2), 24226-24230,
4. Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019; 12(12): 5972-6.
5. Patil SV, Sahoo SK. Spherical Crystallization: a method to improve tabletability. Research Journal of Pharmacy and Technology. 2009; 2(2):234-7.
6. Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8): 624-9.
7. Ranpise AA, Chaudhari SP, Phatak AA, Kadam PM. A review on spherical crystallization-the novel agglomeration technique. Research Journal of Pharmacy and Technology. 2012;5(10):1275-80.
8. Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
9. Yadav AV, Yadav VB. Azithromycin Recrystallized Agglomerates with Hydrophilic Polymers and Surfactant by Neutralization Technique. Research Journal of Pharmacy and Technology. 2009;2(4):796-802.
10. Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
11. Patil SS, Bhokare KK. Study the effects of methacrylic acid copolymers on developed spherical agglomerates of atorvastatin calcium. Research Journal of Pharmacy and Technology. 2012;5(10):1328-34.
12. Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
13. Yadav AV, Yadav VB. Improvement of Physicochemical properties of Mesalamine with Hydrophilic Carriers by Solid Dispersion (kneading) method. Research Journal of Pharmacy and Technology. 2008;1(4):422-5.
14. Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
15. Patil A, Kadam VJ, Jadhav KR. Co-processed Pharmaceutical Excipients–A Brief Review. Research Journal of Pharmacy and Technology. 2010;3(1):50-7.
16. Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
17. Chaudhari P, Uttekar P, Waria N, Ajab A. Study of Different Crystal Habits Formed by Recrystallization Process and Study Effect of Variables. Research Journal of Pharmacy and Technology. 2008;1(4):381-5.
18. Rathi SG, Zala SA, Vaja MD, Vaghela SS. Formulation and evaluation of spherical crystal agglomerates of Lurasidone Hydrochloride. Research Journal of Pharmacy and Technology. 2021 Mar 1;14(3):1238-46.
19. Bika DG, Gentzler M, Michaels JN. Mechanical properties of agglomerates. Powder technology. 2001 Jun 4;117(1-2):98-112.
20. Pawar AP, Paradkar AR, Kadam SS, Mahadik KR. Crystallo-co-agglomeration: A novel technique to obtain ibuprofen-paracetamol agglomerates. AAPS PharmSciTech. 2004 Sep;5(3):57-64.