Author(s): Melica Khatri, Sonam Dhar, Paul Ven, Arjun Singh

Email(s): arjunphar@gmail.com

DOI: 10.52711/2231-5691.2024.00030   

Address: Melica Khatri1, Sonam Dhar1, Paul Ven1, Arjun Singh*2
1Department of Pharmacognosy, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan 305004, India.
2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2024


ABSTRACT:
Anticancer resistance remains a major obstacle in achieving successful outcomes in cancer treatment. Understanding the pharmacological mechanisms underlying resistance is crucial for developing effective strategies to overcome it. This article provides a comprehensive overview of the various pharmacological mechanisms contributing to anticancer resistance, including drug efflux pumps, altered drug targets, drug metabolism and inactivation, DNA repair and damage response, activation of alternative signaling pathways, the tumor microenvironment, epithelial-mesenchymal transition, and cancer stem cells. The article discusses the future directions in this field, such as combination therapies, personalized medicine, immunotherapy, novel drug delivery systems, and biomarker development. Combining multiple strategies and adopting a personalized approach is essential to overcome anticancer resistance and improve treatment outcomes.


Cite this article:
Melica Khatri, Sonam Dhar, Paul Ven, Arjun Singh. Understanding the Pharmacological Mechanisms of Anticancer Resistance: A Multifaceted Challenge in Cancer Treatment. Asian Journal of Pharmaceutical Research. 2024; 14(2):183-7. doi: 10.52711/2231-5691.2024.00030

Cite(Electronic):
Melica Khatri, Sonam Dhar, Paul Ven, Arjun Singh. Understanding the Pharmacological Mechanisms of Anticancer Resistance: A Multifaceted Challenge in Cancer Treatment. Asian Journal of Pharmaceutical Research. 2024; 14(2):183-7. doi: 10.52711/2231-5691.2024.00030   Available on: https://www.asianjpr.com/AbstractView.aspx?PID=2024-14-2-15


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19.    Singh, Aastha, Fatima, K., Srivastava, A., Khwaja, S., Priya, D., Singh, Arjun, Mahajan, G., Alam, S., Saxena, A.K., Mondhe, D.M., Luqman, S., Chanda, D., Khan, F., Negi, A.S., Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer. Chem Biol Drug Des. 2016; 88: 625–634.
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23.    Devender Paswan, Urmila Pande, Alka Singh, Divya Sharma, Shivani Kumar, Arjun Singh. Epidemiology, Genomic Organization, and Life Cycle of SARS CoV-2. Asian Journal of Nursing Education and Research. 2023; 13(2):141-4.
24.    Arjun Singh, Rupendra Kumar, Sachin Sharma. Natural products and Hypertension: Scope and role in Antihypertensive Therapy. Asian Journal of Nursing Education and Research. 2023; 13(2): 162-6.
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33.    Tim F. Dorweiler, Arjun Singh, Richard N Kolesnick, Julia V. Busik; Inhibition of ceramide rich platforms by anti-ceramide immunotherapy prevents retinal endothelial cell damage and the development of diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2023; 64(8): 941.
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